Education

1996-2000  B.S. Biochemistry

East China Normal University (ECNU), China

2000-2005  Ph.D. Neurobiology

Institute of Neuroscience, Chinese Academy of Sciences, China

Academic Experience

2005-2006  Research Associate, Lab of Shumin Duan, Institute of Neuroscience, Chinese Academy of Sciences

2006           Research Associate, Lab of Zuoren Wang, Institute of Neuroscience, Chinese Academy of Sciences

2006           Visiting Scholar, Lab of Chi-Keung Chan, Institute of Physics Academia Sinica, Taiwan

2006-2011  Postdoctoral scholar, Lab of Lily Jan and Yuh Nung Jan, Developmental Neurobiology, University of California, San Francisco/HHMI, USA

2011-2013  Associate specialist, Lab of Lily Jan, University of California, San Francisco/HHMI

2013-2019  Assistant Professor (tenure-track), Children's Research Institute, Department of Pediatrics, Department of Neuroscience, Department of Neurology & Neurotherapeutics, University of Texas Southwestern Medical Center

12/2019-present  Associate Investigator, Chinese Institute for Brain Research, Beijing

Overview of Academic Research

1.  Brain metabolism, brain tumor metabolism, brain vasculature and cerebrovascular diseases.

2.  Technology development for studies of brain metabolism and vasculature.

3.  MS, metabolomics, in vivo imaging, human and mouse genetics, bioinformatics.

Major Honor and Awards

50 Excellent Ph.D. Theses of Chinese Academy of Sciences (2006)

China's Top 10 Advances in Basic Research (2007)

100 Excellent Ph.D. Theses of China (2008)

Human Frontier Science Program Long-term Fellowship Award (2007)

The State Natural Science Award (2nd Contributor, 2010)

NINDS Pathway to Independence Award (K99/R00, 2011)

Bugher-AHA Dan Adams Thinking Outside the Box Award (The Henrietta B. and Frederick H. Bugher Foundation, 2017)

Beijing Young Scholar (2022)

Feng Foundation Scholar of Biomedical Research（2023）

Representative Research Achievements 

1.    Yang Y*, Ge WP*, Chen Y, Zhang Z, Shen W, Wu C, Poo M, Duan S. (2003). Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. Proc Natl Acad Sci U S A. 100(25):15194-15199.

2.    Ge WP*, Yang XJ*, Zhang Z, Wang HK, Shen W, Deng QD, Duan S. (2006). Long-term potentiation of neuron-glia synapses mediated by Ca2+-permeable AMPA receptors. Science. 312(5779):1533-1537.

3.    Chung HJ*, Ge WP*, Qian X, Wiser O, Jan YN, Jan LY. (2009). G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation. Proc Natl Acad Sci U S A. 106(2):635-640.

4.    Ge WP, Zhou W, Luo Q, Jan LY, Jan YN Jan. (2009). Dividing glial cells maintain differentiated properties including complex morphology and functional synapses. Proc Natl Acad Sci U S A. 106(1):328-333

5.    Lee HY, Ge WP, Huang W, He Y, Wang GX, Rowson-Baldwin A, Smith SJ, Jan YN, Jan LY. (2011) Bidirectional regulation of dendritic voltage-gated potassium channels by the fragile X mental retardation protein. Neuron 72(4); 630-642

6.    Ge WP, Miyawaki A, Gage FH, Jan YN, Jan LY. (2012) Local generation of glia is a major astrocyte source in postnatal cortex. Nature 484(7394); 376-380.

7.    Jia JM, Chowdary PD, Gao X, Ci B, Li W, Mulgaonkar A, Plautz EJ, Hassan G, Kumar A, Stowe AM, Yang SH, Zhou W, Sun X, Cui B*, Ge WP* (2016) Control of cerebral ischemia with magnetic nanoparticles. Nat Methods. 14(2):160-166. doi: 10.1038/nmeth.4105.

8.    Huang L, Chambliss KL, Gao X, Yuhanna IS, Behling-Kelly E, Bergaya S, Ahmed M, Michaely P, Luby-Phelps K, Darehshouri A, Xu L, Fisher EA, Ge WP, Mineo C, Shaul PW.  SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis. Nature. (2019);569(7757):565-569.

9.    Gao X, Zhang Z, Mashimo T, Shen B, Nyagilo J, Wang H, Wang Y, Liu Z, Mulgaonkar A, Hu XL, Piccirillo SGM, Eskiocak U, Davé DP, Qin S, Yang Y, Sun X, Fu YX, Zong H, Sun W, Bachoo RM, Ge WP. Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles. Cell Reports. 2020;30(8):2489-2500.e5.

10.   Xiong N*, Gao X, Zhao H, Cai F, Zhang FC, Yuan Y, Liu W, He F, Zacharias LG, Lin H, Vu HS, Xing C, Yao DX, Chen F, Luo B, Sun W, DeBerardinis RJ, Xu H, Ge WP* Using arterial-venous analysis to characterize cancer metabolic consumption in patients. Nature Communications (2020) 11(1):3169.

11.    Ren J, Huang Y, Ren Y, Tu T, Qiu B, Ai D, Bi Z, Bai X, Li F, Li JL, Chen XJ, Feng Z, Guo Z, Lei J, Tian A, Cui Z, Lindner V, Adams RH, Wang Y, Zhao F, Körbelin J, Sun W, Wang Y, Zhang H, Hong T, Ge WP. Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations. Brain (2023) 146(9):3634-3647.

12.    Zhang D, Ruan J, Peng S, Li J, Hu X, Zhang Y, Zhang T, Ge Y, Zhu Z, Xiao X, Zhu Y, Li X, Li T, Zhou L, Gao Q, Zheng G, Zhao B, Li X, Zhu Y, Wu J, Li W, Zhao J, Ge WP, Xu T, Jia JM. Synaptic-like transmission between neural axons and arteriolar smooth muscle cells drives cerebral neurovascular coupling. Nature Neuroscience. 2024; 27(2): 232-248.

13.    Zhang T, Ai D, Wei P, Xu Y, Bi Z, Ma F, Li F, Chen XJ, Zhang Z, Zou X, Guo Z, Zhao Y, Li JL, Ye M, Feng Z, Zhang X, Zheng L, Yu J, Li C, Tu T, Zeng H, Lei J, Zhang H, Hong T, Zhang L, Luo B, Li Z, Xing C, Jia C, Li L, Sun W, Ge WP. The subcommissural organ regulates brain development via secreted peptides. Nature Neuroscience 2024 27(6):1103-1115. PMID: 38741020.

14.    Ai D, Ming T, Li X, Wang S, Bi Z, Zuo J, Cheng Z, Sun W, Xie M, Li F, Wang X, Qi X, Luan G, Ge WP*, Guan Y*. Transcriptomic Profiling Unveils EDN3+ Meningeal Fibroblasts as Key Players in Sturge-Weber Syndrome Pathogenesis. Advanced Science (Weinh). 2025 Feb 8:e2408888. doi: 10.1002/advs.202408888. Online ahead of print. PMID: 39921427.

15.    Gao X, Li JL, Chen X, Ci B, Chen F, Lu N, Shen B, Zheng L, Jia J, Yi Y, Zhang S, Shi Y, Shi K, Propson NE, Huang Y, Poinsatte K, Zhang Z, Yue Y, Bosco DB, Lu YM, Yang SB, Adams RF, Lindner V, Huang F, Wu LJ, Zheng H, Han F, Hippenmeyer S, Stowe AM, Peng B, Margeta M, Wang X, Liu Q, Korbelin J, Trepel M, Lu H, Zhou BO, Zhao H, Sun W, Bachoo RM, Ge WP. Reduction of neuronal activity mediated by blood-vessel regression in the brain. Nature Communications 2025 Jul 1;16(1):5840. PMID: 40595484.

16.    Wang Y, Zhou L, Wang N, Qiu B, Yao D, Yu J, Li T, He M, Xie Y, Yu X, Bi Z, Sun X, Ji X, Li Z, Mo D, Ge WP, Comprehensive characterization of metabolic consumption and production by the human brain, Neuron, 113, 1-15, Mar. 26, 2025 online, June 4, 2025 in print).

17.    Li JL, Bi Z, Chen XJ, Ming T, Qiu B, Li F, Feng Z, Ai D, Zhang T, Wang J, Lin S, Lu Y, Wang Z, Huang J, Zhao F, Zhao H, Wang Y, Sun W, Ge WP. rAAV-miniBEND: A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modeling, Nature Biomedical Engineering (2025/8, in print, bioRxiv 2025.06.10.658979; doi: https://doi.org/10.1101/2025.06.10.658979)